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Venkateshwara Rao, J.
- A New Simple RP-HPLC Method for Simultaneous Estimation of Asprin, Atorvastatin and Clopidogrel in Capsule Dosage Form
Authors
1 Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maissamaguda, Dullapally, Secunderabad-14, Andrapradesh, IN
2 Department of Pharmaceutical Chemistry, Sultan Ul Uloom College of Pharmacy, Road No3, Banjara Hills , Secunderabad-500034, Andra pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 795-799Abstract
The working conditions for the high pressure liquid Chromatography method was established for Asprin, Atorvastatin and Clopidogrel and then applied on pharmaceutical dosage forms. A rapid sensitive of Chromarographic separation was accomplished using hypersil BDS C18 (250×4.6 mm, 5μ) analytical column with mobile phase consisting of, acetonitrile, water (pH 3)and methanol (50:40:10 v/v). The eluent were detected by UV absorbance at 248 nm. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability. The proposed method can be used for the estimation of these drugs in combined pharmaceutical dosage forms.Keywords
Simultaneous Estimation, Asprin, Atorvastatin, Clopidogrel.- A Novel Co-crystallization Technique to Enhance the Physicochemical Property of Bcs Class-ii Drugs Using Efavirenz as a Model Drug
Authors
1 Government College of Pharmacy, Karad, Dist.– Satara – 415004 Maharashtra,, IN
2 Government College of Pharmacy, Ratnagiri, 415612, Maharashtra, IN
3 Global College of Pharmacy, Moinabad, R.R. Dist., Telangana State, 501504, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1603-1609Abstract
Pharmaceutical co-crystallization, a novel technique, provides for alteration and tailoring of physicochemical properties of active pharmaceutical ingredients (API) notwithstanding maintaining the intrinsic activity of the drug molecule. In the present work, co-crystals of efavirenz (EFA) were prepared with selected conformers of GRAS (Generally Recognized as Safe) status wise salicylic acid (SA) and benzoic acid (BA) using solution crystallization method to improve its dissolution. The assembly of crystal structure was evaluated by means of fourier transformation infrared spectroscopy (FTIR), x-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and nuclear magnetic resonance (NMR). Saturation solubility and in vitro dissolution studies were further employed to investigate co-crystals. Equilibrium solubility profile of EFA-SA and EFA-BA exhibits an enhancement of 1.60 and 1.29 folds of solubility of efavirenz co-crystals as compared to the pure drug. Pharmacokinetic study performed in rats showed AUC0-∞ for co-crystals formulation was higher (13.15±0.02μg hmL−1) than the pure drug suspension formulation 7.85±0.03μg hmL−1. Statistically, AUC0-t of the co-crystal formulation was significantly higher (p<0.05) as compared to pure drug suspension formulation. Higher amount of drug concentration in blood indicated better systemic absorption of efavirenz from co-crystals formulation as compared to the pure drug suspension formulation.
Keywords
Pharmaceutical co-crystallization, Physicochemical properties, Co-crystals, Aqueous solubility.References
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